Increased Levels of Platelet-Related miRNAs Associated With Severe AD
The platelet-related miRNAs miR-24 and miR-191 may be responsible for worsening atopic dermatitis (AD), according to a recent study published in Clinical Immunology.
Researchers aimed to determine the platelet-related miRNA (miR-24 and miR-191) levels in the plasma of patients with AD and their relationships with disease severity and laboratory data using specifically primed quantitative reverse transcription polymerase chain reaction.
Higher levels of plasma miR-191 were found in patients with severe AD compared with patients with mild AD, patients with urticaria, and the healthy volunteers. The plasma miR-24 and miR-191 levels in patients with AD were correlated with their serum thymus levels, activation-regulated chemokine levels, and plasma levels of platelet factor 4 and β-thromboglobulin.
“Our findings imply that miR-24 and miR-191 may be involved in the pathomechanisms responsible for the worsening of AD, possibly through their effects on platelet activation,” concluded the study authors.
1. Maeno M, Tamagawa-Mineoka R, Arakawa Y, et al. Increased plasma miR-24 and miR-191 levels in patients with severe atopic dermatitis: Possible involvement of platelet activation. Clin Immunol. Published online March 18, 2022. doi:10.1016/j.clim.2022.108983