Probiotics Could Lower the Risk of Infantile Atopic Dermatitis
Results of a study published in Oxidative Medicine and Cellular Longevity suggest that women taking probiotics could lower the risk of infantile atopic dermatitis (AD) during late stages of pregnancy excluding IgE-associated infant AD or sensitive constitution.
Researchers retrieved randomized controlled trials (RCTs) conducted until November 20, 2021, to analyze the association between probiotics and AD. All trials were pulled from PubMed, Web of Science, Embase, and China National Knowledge Infrastructure. Meta-analysis, sensitivity analysis, and bias analysis utilized stata 12.0, and random or fixed effect models were pooled according to heterogeneity.
About 8 trials had 2575 infants extracted who met the qualification criteria. Researchers found that probiotics significantly reduced incidence of childhood AD compared to placebo; however, there was no evidence of probiotics preventing the development of either IgE-associated infant AD or sensitive constitution.
“From the results of sensitivity and publication bias, we found that these results were robust with little publication bias,” researchers stated, “The results could provide evidence for the fibrosis. Future studies are needed to confirm the results,” they added.
Pan H, Su J. Association of probiotics with atopic dermatitis among Infant: a meta-analysis of randomized controlled trials. Oxid Med Cell Longev. Published online May 23, 2022. doi:10.1155/2022/5080190